DOI: 10.53524/lit.edt.978-65-995572-5-5/13
PALAVRAS CHAVE: Feridas. Curativo. Nanopartículas.
KEYWORDS: Wound. Dressing. Nanoparticle.
ABSTRACT: OBJECTIVE: To analyze the biological effects and clinical implications of nano-silver in the treatment of wounds. METHODS: This was a qualitative systematic review, prepared according to the PRISMA methodology (Key Items for Reporting Systematic Reviews and Meta-analyses). We searched for studies published in the Pubmed and Embase databases, using the Decs/MESH descriptors: “Wounds”, “Curative” and “Nanoparticles” and their correspondents in English. Se incluyeron ensayos clínicos aleatorizados y no aleatorizados, disponibles en línea, con texto completo, en portugués e inglés y publicados entre 2012 y mayo de 2022. Randomized and non-randomized clinical trials, available online, with full text, in Portuguese and English and published from 2012 to May 2022, were included. Regarding the methodological analysis, we chose to select articles with scores above 70% on the STROBE scale. RESULTS: After analysis, 08 articles were considered eligible to compose this systematic review. There are indications in the literature of modulation of the inflammatory response by the action of silver, justified by its ability to reduce the levels of pro-inflammatory markers and because it is involved in the alteration or suppression of inflammatory events in the initial stages of wound healing. CONCLUSION: Nano-silver dressings proved to be effective for re-epithelialization, healing, antimicrobial action, ease of application and tolerance. The development of nano-silver materials combined with continuous research can improve the material' s performance in physical, chemical and biological aspects.
Anildo Alves de Brito Júnior
Jean Nunes dos Santos
Jeisielle Alves da Anunciação Barreto
Juliana Monteiro Azevedo
Susana Carla Pires Sampaio de Oliveira
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Desenvolvido por Alexsander Arcelino