INFECÇÃO PELO VÍRUS LINFOTRÓPICO DE CÉLULAS T HUMANAS (HTLV) E O TRANSTORNO DEPRESSIVO: EVIDÊNCIAS DE UMA RELAÇÃO COMPLEXA E POUCO RECONHECIDA

DOI: 10.53524/lit.edt.978-65-84528-66-6/11

PALAVRAS-CHAVE: Infecções por HTLV-I. Transtorno Depressivo. Doenças Neuroinflamatórias. Saúde Mental. Qualidade de Vida.

KEYWORDS: HTLV-I Infections. Depressive Disorder. Neuroinflammatory Diseases. Mental Health. Quality of Life.

ABSTRACT: OBJECTIVE: Discuss evidence on the association between HTLV-1 infection and depressive disorder, considering biological
mechanisms, clinical repercussions, and psychosocial determinants. METHODS: Narrative, descriptive, and critical-reflective
review based primarily on MEDLINE/PubMed searches combining the terms “HTLV”, “depression”, “central nervous system”,
and “neuroinflammation”. Publications were selected non-systematically according to thematic relevance, recency, and
contribution to the discussion. RESULTS AND DISCUSSION: Depression is highly prevalent among people living with HTLV-
1, affecting approximately 35% of this population, with odds about 4.25 times higher than those observed in seronegative
individuals. This magnitude appears to result from the interaction of biological, clinical, and psychosocial mechanisms.
Relevant factors include chronic neuroinflammation, production of pro-inflammatory cytokines, and central nervous system
alterations, as well as motor disability, chronic pain, urogenital dysfunction, stigma, and socioeconomic vulnerability. The
coexistence of these dimensions may intensify psychological distress and impair quality of life. FINAL CONSIDERATIONS:
Mental health should be incorporated into the care of people living with HTLV-1. Further clinical and translational studies are
needed to clarify underlying mechanisms and identify biomarkers capable of predicting depression and neurological
progression.

Autor

  • Daniel Moreira Alves da Silva

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Desenvolvido por Alexsander Arcelino